Synthetic Biology is an emerging discipline aiming at applying engineering principles to biology. The goal is to better understand how biological systems work and to produce valuable applications.
In the Synthetic Biology part of the course (20h) we will introduce basic engineering concepts of standardisation, abstraction hierarchies, forward/inverse engineering, system control theory. We will also provide background knowledge to understand some experimental tools largely used in the field (PCR, sequencing, DNA synthesis, CRISPR/Cas system). We will then introduce quantitative modelling techniques of transcription and translation as tools for designing sequences and genetic circuits (e.g. logic gates and switches). Finally, the societal impact of Synthetic Biology will be discussed.
Every week we will suggest papers and chapters of books that the students will need to read before coming to the lecture. A brief summary of a few hundred words will be asked before each lecture.
Throughout the course students will develop short interdisciplinary and creative project proposals in teams mixing modelers and experimentalists. The projects will be presented orally at the end of the term.
The course can be given in English.
- Enseignant: Ciandrini Luca
- Enseignant: Walliser Nils Ole